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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

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A Patient-Derived Xenograft Model for Venous Malformation
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A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

Cutaneous vascular disorders associated with internal malignancy.

Abdel Kader El Tal1, Zeina Tannous

  • 1Department of Dermatology, Oakwood Hospital, Cancer Center Clinic, Wayne State University, 18101 Oakwood Boulevard, Dearborn, MI 48123, USA.

Dermatologic Clinics
|November 21, 2007
PubMed
Summary

Skin vascular changes like flushing and purpura can signal internal cancers. Early recognition by dermatologists aids in timely diagnosis and treatment of these underlying malignancies.

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Area of Science:

  • Dermatology
  • Oncology
  • Vascular Medicine

Background:

  • Internal malignancies can manifest with various cutaneous vascular abnormalities.
  • These include disorders of vascular dilatation (e.g., flushing, palmar erythema, telangiectasia) and vascular occlusion/hypercoagulability (e.g., purpura, cutaneous ischemia, thrombophlebitis).

Purpose of the Study:

  • To review the association between skin vascular manifestations and internal malignancies.
  • To guide dermatologists in recognizing these signs for prompt workup and management.

Main Methods:

  • Comprehensive literature review of vascular abnormalities linked to internal cancers.
  • Categorization of vascular changes based on etiology and clinical presentation.
  • Discussion of diagnostic and therapeutic approaches, emphasizing underlying malignancy treatment.

Main Results:

  • Vascular changes are categorized into dilatation and occlusion/hypercoagulability disorders.
  • Specific examples include flushing, palmar erythema, telangiectasia, purpura, cutaneous ischemia, and thrombophlebitis.
  • Treatment primarily involves addressing the associated internal malignancy.

Conclusions:

  • Cutaneous vascular manifestations serve as potential indicators of internal malignancies.
  • Dermatologists play a crucial role in identifying these signs.
  • Prompt recognition facilitates early diagnosis and improves patient outcomes.