Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Applications of Reflectance Confocal Microscopy in Paediatric Dermatology: A Systematic Review.

Experimental dermatology·2026
Same author

Human Genome Promise-Are We There Yet?

JAMA dermatology·2026
Same author

Geographic variation in the impact of novel melanoma therapies on mortality.

Journal of the American Academy of Dermatology·2026
Same author

Differential stability of NRAS and BRAF oncoproteins in melanoma.

The Journal of investigative dermatology·2026
Same author

Germline inactivation of tumor suppressor BAP1 is associated with white spotting.

The Journal of clinical investigation·2026
Same author

KIT-Mutant Melanoma: Understanding the Pathway to Personalized Therapy.

Cancers·2025

Related Experiment Video

Updated: Jul 10, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Genodermatoses with cutaneous tumors and internal malignancies.

Brian Somoano1, Hensin Tsao

  • 1Department of Dermatology, Stanford University Medical Center, 900 Blake Wilbur Drive, Stanford, CA 94305, USA.

Dermatologic Clinics
|November 21, 2007
PubMed
Summary

Genodermatoses are genetic skin disorders that can increase cancer risk. Understanding their molecular basis aids early diagnosis and reduces cancer-related illness.

Related Experiment Videos

Last Updated: Jul 10, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Area of Science:

  • Genetics
  • Dermatology
  • Oncology

Background:

  • Genodermatoses are genetic disorders presenting with skin abnormalities.
  • Some genodermatoses are linked to an increased risk of developing cutaneous and internal tumors.
  • Familial cancer syndromes are increasingly understood through advanced genetic technologies.

Purpose of the Study:

  • To review genodermatoses associated with both skin and other tumors.
  • To highlight recent findings on clinical presentation and molecular causes.
  • To emphasize the importance of early diagnosis for reducing cancer morbidity.

Main Methods:

  • Literature review of genodermatoses with tumor predisposition.
  • Focus on recent advancements in understanding molecular etiology.
  • Analysis of clinical manifestations and genetic underpinnings.

Main Results:

  • Identified genodermatoses with significant tumor susceptibility.
  • Detailed current knowledge on clinical features and molecular pathways.
  • Highlighted the link between specific genetic defects and cancer development.

Conclusions:

  • Familiarity with these genodermatoses is crucial for early detection.
  • Understanding molecular etiology aids in risk stratification and management.
  • Prompt diagnosis and management can significantly minimize morbidity from associated malignancies.