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Updated: Jul 10, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
Genodermatoses with cutaneous tumors and internal malignancies
1Department of Dermatology, Stanford University Medical Center, 900 Blake Wilbur Drive, Stanford, CA 94305, USA.
Abstract:
The genodermatoses reflect a diverse group of disorders characterized by cutaneous findings associated with an underlying genetic defect. A subset of these conditions are known to confer a susceptibility to the development of cutaneous and internal tumors. Powerful genetic technologies are continuously advancing our understanding of the molecular basis of these familial cancer syndromes. This article reviews those genodermatoses with cutaneous and extracutaneous tumors, focusing on recent insight into their clinical presentation and molecular etiology, because familiarity with these may facilitate early diagnosis and minimize morbidity from their associated malignancies.
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