Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A final common pathway for depression? Progress toward a general conceptual framework.

Eric A Stone1, Yan Lin, David Quartermain

  • 1Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA. eric.stone@nyu.edu

Neuroscience and Biobehavioral Reviews
|November 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Path2Omics Enhances Transcriptomic and Methylation Prediction Accuracy from Tumor Histopathology.

Cancer research·2025
Same author

Protein evolution as a complex system.

Nature chemical biology·2025
Same author

Path2Omics: Enhanced transcriptomic and methylation prediction accuracy from tumor histopathology.

bioRxiv : the preprint server for biology·2025
Same author

Genome Biology of Rust Fungi.

Annual review of phytopathology·2025
Same author

Characterization of Virulence of <i>Puccinia coronata</i> f. sp. <i>avenae</i> in Australia in the 2023 Growing Season.

Plant disease·2025
Same author

A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics.

Nature cancer·2024
Same journal

Peripheral Nervous System Involvement in Parkinson's Disease: Peripheral Neuropathy, Neuromuscular Junction Dysfunction, and Clinical Implications.

Neuroscience and biobehavioral reviews·2026
Same journal

Violence on the self: Exploring the intersection of trauma and identity among sexual and gender minorities from a neurobiological and developmental perspective to advance our understanding of PTSD, moral injury, and dissociation symptoms.

Neuroscience and biobehavioral reviews·2026
Same journal

Meaning in life and biological functioning: A multisystem synthesis and agenda for future research.

Neuroscience and biobehavioral reviews·2026
Same journal

Beyond Diagnosis: Why and How Virtual Reality Should be Used in Research on Neurodevelopmental Conditions?

Neuroscience and biobehavioral reviews·2026
Same journal

What eye-movements tell us about Disorders of Consciousness?

Neuroscience and biobehavioral reviews·2026
Same journal

Systematic Review of Tactile-Based Interventions Combined with Multisensory Stimulation Protocols in the Rehabilitation of Patients with Disorders of Consciousness.

Neuroscience and biobehavioral reviews·2026
See all related articles

Depression involves hypoactivity in positive motivation brain regions and hyperactivity in stress response areas. Antidepressant treatments reverse these neural patterns, suggesting a new framework for understanding depression symptoms and treatments.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Depression is characterized by hypoactivity in brain regions associated with positive motivation and hyperactivity in stress response regions.
  • These neural changes are observed in both human patients and animal models of depression.
  • Existing antidepressant treatments reverse these observed neural alterations.

Purpose of the Study:

  • To propose a neural framework for understanding depression.
  • To organize diverse findings related to depression, including neurotransmitters, cytokines, corticosteroids, and neurotrophins.
  • To explore the relationship between motivational networks, stress responses, and antidepressant mechanisms.

Main Methods:

  • Review and synthesis of functional neuroimaging studies in depressed patients.

Related Experiment Videos

  • Integration of functional brain mapping studies in depressed animal models.
  • Analysis of the effects of various neurochemical and hormonal factors on depression.

    • Main Results:

    • A consistent neural pattern of hypoactive positive motivation networks and hyperactive stress networks in depression.
    • Reversal of this neural pattern by various antidepressant treatments.
    • The proposed framework organizes findings on monoamines, cytokines, corticosteroids, and neurotrophins.

    Conclusions:

    • The neural pattern of hypoactive positive motivation and hyperactive stress response networks underlies core depression symptoms.
    • This framework offers insights into neurotrophic support, corticosteroid treatment efficacy, and antidepressant mechanisms.
    • Further research is needed to determine if antidepressants primarily inhibit stress networks or enhance positive motivational systems.