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Related Experiment Video

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Mouse Models of Periventricular Leukomalacia

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Published on: May 18, 2010

Reversible posterior leukoencephalopathy syndrome.

Jeong Mi Moon¹, Byeong Jo Chun

¹Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, South Korea.

The Journal of Emergency Medicine

|November 21, 2007

Summary

Reversible posterior leukoencephalopathy syndrome (RPLS) can occur with lower blood pressure than previously thought, especially with fever. This case highlights RPLS in a postpartum patient following amniotic fluid embolism.

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Area of Science:

Neurology
Obstetrics
Radiology

Background:

Reversible posterior leukoencephalopathy syndrome (RPLS) is a neurological condition linked to high blood pressure or immunosuppressants.
RPLS presents with posterior cerebral edema on imaging.

Observation:

A 30-year-old mother developed RPLS five days after cesarean delivery and resuscitation from cardiorespiratory collapse due to amniotic fluid embolism.
The patient experienced seizures and radiological findings consistent with RPLS.

Findings:

This case suggests RPLS may manifest at lower blood pressure thresholds than previously recognized.
Fever may be a critical co-factor in the development of RPLS.

Implications:

Clinicians should consider RPLS in postpartum patients with neurological symptoms, even with moderate hypertension.
Monitoring blood pressure control, particularly in the presence of fever, is crucial for preventing RPLS in susceptible individuals.