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Related Experiment Video

Updated: Jul 10, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

Completion mastectomy after breast conserving surgery.

M E O'Donnell1, A Salem, S A Badger

  • 1Multidisciplinary Breast Unit, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK. modonnell904@hotmail.com <modonnell904@hotmail.com>

Breast (Edinburgh, Scotland)
|November 21, 2007
PubMed
Summary

Tumor size is a key factor in predicting residual breast cancer after breast-conserving surgery (BCS). Larger tumors (>2.5 cm) significantly increase the likelihood of needing a completion mastectomy due to positive margins.

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Breast Cancer Research

Background:

  • Breast-conserving surgery (BCS) is a common treatment for early-stage breast cancer.
  • Positive pathological margins after BCS can necessitate further surgery.
  • Identifying patients at risk for positive margins is crucial for surgical planning.

Purpose of the Study:

  • To determine the rate of completion mastectomy after BCS in a specific patient cohort.
  • To identify predictive factors for positive margins following BCS.
  • To aid surgeons in selecting appropriate candidates for BCS versus mastectomy.

Main Methods:

  • Retrospective review of early-stage breast cancer patients (2001-2005).
  • Histopathological examination of BCS specimens for margin involvement.

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Last Updated: Jul 10, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
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Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

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  • Multinomial logistic regression analysis of clinico-pathological factors.
  • Correlation of initial tumor size with need for completion mastectomy.

    • Main Results:

    • Initial tumor size was the sole significant predictor of completion mastectomy residual carcinoma (CMRC).
    • Tumors > 2.5 cm were 15 times more likely to require completion mastectomy than tumors < 1.5 cm.
    • Odds ratios for CMRC increased with tumor size for various histological types.

    Conclusions:

    • Residual disease after BCS is strongly associated with increasing original tumor size.
    • Tumor size > 2.5 cm is a critical threshold for considering primary mastectomy.
    • Surgeons can use tumor size to counsel patients on BCS risks and optimize treatment decisions.