Copper(II) complexes with bioactive carboxyamide: synthesis, characterization and biological activity
Bibhesh K Singh1, Narendar Bhojak, Parashuram Mishra
1Department of Chemistry, University of Delhi, Delhi 110007, India. bibheshksingh@yahoo.co.in
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|November 21, 2007
Summary
New copper(II) complexes with bioactive carboxyamide ligands were synthesized and characterized. These metal complexes exhibit significant antimicrobial properties against bacteria and fungi.
Area of Science:
- Coordination Chemistry
- Materials Science
- Biochemistry
Background:
- Carboxyamide ligands are known for their biological activity.
- Copper(II) complexes are investigated for various applications, including antimicrobial uses.
Purpose of the Study:
- To synthesize and characterize novel copper(II) complexes with specific carboxyamide ligands.
- To evaluate the antimicrobial efficacy of these synthesized ligands and their copper(II) complexes.
Main Methods:
- Synthesis and characterization using physico-chemical techniques (Mass spectrometry, Vibrational, Electronic, EPR spectra, Magnetic susceptibility).
- Electrochemical analysis using cyclic voltammetry.
- Thermal analysis (Coats and Redfern method).
- In vitro antimicrobial activity testing against bacteria and pathogenic fungi.
Main Results:
- Successful synthesis and characterization of copper(II) complexes with carboxyamide ligands.
- Spectroscopic and magnetic data indicate octahedral geometry for the Cu(II) complexes.
- Electrochemical studies reveal a Cu(II)/Cu(I) redox process.
- Kinetic and thermodynamic parameters confirm first-order kinetics.
- The synthesized ligands and their copper(II) complexes demonstrate notable in vitro antimicrobial activity.
Conclusions:
- The synthesized copper(II) complexes possess octahedral geometry and exhibit promising antimicrobial properties.
- These findings suggest potential applications of these novel complexes as antimicrobial agents.
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