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Published on: February 19, 2019
[Expression of B7-H1 on peripheral blood mononuclear cells from chronic hepatitis B patients]
Zhun-yi Xie1, Yong-wen Chen, Xiao-lan Fu
1Institute of Immunology of PLA, Third Military Medical University, Chongqing 400038, China. 3132xzy@mail.tmmu.com.cn
Objective:
To investigate the expression of B7-H1 on peripheral blood mononuclear cells from patients with chronic HBV infection.
Methods:
Immunofluorescent staining and flow cytometry assay were used to measure the expression of B7-H1 on peripheral blood CD3high T cells, CD19high B cells and CD14high monocytes from chronic HBV infected patients.
Results:
No significant difference was observed in B7-H1 expression on T cells and B cells between chronic HBV infected patients (CHB) and health controls (HC). B7-H1-expressing CD14high cells were significantly increased in chronic HBV-infected patients (19.17-/+11.64)% as compared with healthy controls [(7.30-/+5.49)%, P<0.01]. A significant positive correlation was found between B7-H1 expression on CD14high monocytes and serum ALT levels.
Conclusion:
There is no significant difference in B7-H1 expression on T cells and B cells between CHB patients and healthy subjects. B7-H1, which is up-regulated on monocytes from chronic HBV-infected patients, in positively correlated to serum ALT levels, and may play a role in the persistence of HBV infection.
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