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[Preparation of gemcitabine polybutylcyanoacrylate nanoparticles]
Le-song Huang1, Chun-xia Wang, Zhi-liang Chen
1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. hls83@fimmu.com
Objective:
To optimize the preparation process of gemcitabine polybutylcyanoacrylate nanoparticles (GCTB- PBCA-NP).
Methods:
According to the particle size, the entrapment efficiency and the loading quantity of GCTB-PBCA-NP, single factor analysis was carried out to optimize the component composition and preparation process based on an orthogonal design.
Results:
The mean particle size of the NP was (112-/+9) nm with an entrapment efficiency of (54.12-/+2.43)% and drug loading of (11.08-/+0.89)%.
Conclusion:
An optimized nanoparticular drug delivery system is obtained by emulsion polymerization.
