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Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity

Benjamin P Woodall1, Alexander Nyström, Rex A Iozzo

  • 1Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

The Journal of Biological Chemistry
|November 21, 2007
PubMed
Summary

Endorepellin, a perlecan module, stops blood vessel growth by binding to the alpha2beta1 integrin receptor. This interaction is crucial for endorepellin's anti-angiogenic effects in cancer.

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