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Updated: Jul 10, 2026
RNA Interference-based Investigation of the Function of Heat Shock Protein 27 during Corneal Epithelial Wound Healing
Published on: September 27, 2016
Plasma concentration of heat shock protein 27 and risk of cardiovascular disease: a prospective, nested case-control
Isabella Kardys1, Nader Rifai, Olivier Meilhac
1Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA. i.kardys@erasmusmc.nl
Background:
Heat shock protein 27 (HSP27) has been hypothesized to be a potential biomarker of atherothrombosis. However, no prospective studies have yet been performed to investigate the association between HSP27 plasma concentration and incident cardiovascular events among initially healthy individuals.
Methods:
We evaluated plasma concentrations of HSP27 at baseline among 255 initially healthy participants in the Women's Health Study who subsequently developed myocardial infarction, ischemic stroke, or cardiovascular death during a follow-up period of up to 5.9 years and among an equal number of women matched for age and smoking but who remained free of cardiovascular disease over the same time period.
Results:
Overall, HSP27 plasma concentrations were inversely associated with age (Spearman correlation coefficient r = -0.258, P <0.001), but not with other established cardiovascular risk factors. Conditional logistic regression analysis showed no significant association of baseline HSP27 plasma concentration with future cardiovascular disease; the odds ratio for upper vs lower tertile of HSP27 concentration at baseline was 0.99 (95% CI 0.62-1.57, P for trend = 0.99).
Conclusion:
In this prospective study of initially healthy women, baseline HSP27 plasma concentration was not associated with incident cardiovascular events.
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