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Related Experiment Video

Updated: Jul 10, 2026

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Evidence-based platelet transfusion guidelines.

Sherrill J Slichter¹

¹Platelet Transfusion Research, Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104-1256, USA. sjslichter@psbc.org

Hematology. American Society of Hematology. Education Program

|November 21, 2007

Summary

Platelet transfusions are effective when stored for 5 days. Specific transfusion triggers and leukoreduction strategies improve outcomes, though some benefits remain under investigation. Managing poor responses requires addressing multifactorial causes.

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Routine Screening Method for Microparticles in Platelet Transfusions

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Published on: January 31, 2018

Area of Science:

Transfusion Medicine
Hematology

Background:

Platelet (plt) products include pooled random-donor and single-donor apheresis platelets.
Stored platelet products are equally efficacious up to 5 days.

Purpose of the Study:

To review current practices and evidence regarding platelet transfusion efficacy, triggers, and management of poor responses.
To highlight the role of leukoreduction and address controversies surrounding its universal application.

Main Methods:

Review of existing literature and clinical trial data on platelet transfusion efficacy and triggers.
Discussion of factors influencing platelet transfusion response, including alloimmunization and non-immune causes.

Main Results:

Prophylactic platelet transfusion triggers of 10,000/microL are hemostatically effective and cost-efficient.
Therapeutic transfusion triggers vary by procedure: 100,000/microL for neurosurgery, 50,000-100,000/microL for other invasive procedures/trauma.
Leukoreduction reduces alloimmunization, CMV transmission, and febrile reactions; immunomodulatory benefits are debated.

Conclusions:

Established transfusion triggers provide hemostatic efficacy.
Leukoreduction offers documented benefits, but universal application and immunomodulatory effects require further research.
Poor platelet transfusion responses are multifactorial, necessitating tailored management strategies.