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Related Experiment Video

Updated: Jul 10, 2026

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

Published on: July 2, 2016

Complete genome sequences for nine simian enteroviruses.

M Steven Oberste¹, Kaija Maher¹, Mark A Pallansch¹

¹Polio and Picornavirus Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

The Journal of General Virology

|November 21, 2007

Summary

This summary is machine-generated.

Simian enteroviruses show distinct genetic relationships, with some belonging to known human enterovirus species (HEV-A, HEV-B) and others representing novel species. Host species significantly influences the evolution of non-capsid enterovirus sequences.

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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

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Published on: June 11, 2015

Area of Science:

Virology
Molecular Evolution
Genomics

Background:

Enteroviruses are a genus of picornaviruses with significant human and animal health implications.
Previous analysis of VP1 capsid sequences suggested classifications for several simian enteroviruses.
Further genomic characterization is needed to fully understand simian enterovirus diversity and evolution.

Purpose of the Study:

To perform complete genomic sequencing of simian enteroviruses.
To elucidate the genetic relationships among simian enteroviruses and with other enteroviruses.
To investigate the evolutionary influence of host species on enterovirus non-capsid sequences.

Main Methods:

Complete genomic sequencing of eight simian enterovirus serotypes.
Phylogenetic analysis of P1, P2, and P3 regions.
Pairwise sequence comparison of VP1, 2C, 3CD, and 3'-non-translated regions (NTR).

Main Results:

Phylogenetic analysis of the P1 region confirmed that SV4/A-2 plaque virus, SV6, and N125/N203 represent three new species.
Sequence relationships in the P2 and P3 regions revealed different clustering patterns compared to P1.
Simian enterovirus 3'-NTRs are distinct from human enteroviruses and generally from each other, suggesting host-specific evolution.

Conclusions:

Simian enteroviruses exhibit complex genetic diversity, with some aligning to human enterovirus species A and B, while others constitute new species.
Enterovirus evolution, particularly in non-capsid regions, appears to be significantly influenced by the host species.
Complete genomic analysis provides a more comprehensive understanding of enterovirus diversity and evolutionary dynamics.