Related Experiment Video
Updated: Jul 10, 2026

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation
Published on: May 18, 2020
Interaction between control and design of a SHARON reactor: economic considerations in a plant-wide (BSM2) context
E I P Volcke1, M C M van Loosdrecht, P A Vanrolleghem
1BIOMATH, Department of Applied Mathematics, Biometrics and Process Control, Ghent University, Coupure links 653, B-9000, Gent, Belgium. eveline.volcke@biomath.ugent.be
Abstract:
The combined SHARON-Anammox process is a promising technique for nitrogen removal from wastewater streams with high ammonium concentrations. It is typically applied to sludge digestion reject water, in order to relieve the activated sludge tanks, to which this stream is typically recycled. This contribution assesses the impact of the applied control strategy in the SHARON-reactor, both on the effluent quality of the subsequent Anammox reactor as well as on the plant-wide level by means of an operating cost index. Moreover, it is investigated to which extent the usefulness of a certain control strategy depends on the reactor design (volume). A simulation study is carried out using the plant-wide Benchmark Simulation Model no. 2 (BSM2), extended with the SHARON and Anammox processes. The results reveal a discrepancy between optimizing the reject water treatment performance and minimizing plant-wide operating costs.
Related Concept Videos
Bioreactor Controls-I
Bioreactor Design and Operational System
Nuclear Power
Nuclear Fuels
Nuclear fuel consists of a fissile isotope, such as uranium-235, which must be present in sufficient quantity to provide a...
Bioreactor Controls-II
Bioreactor Controls-III
Control of Power Flow
