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Chronic kidney disease as a risk factor for coronary artery disease in Chinese with type 2 diabetes

Ming-Chia Hsieh1, Jeng-Yueh Hsiao, Kai-Jen Tien

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

American Journal of Nephrology
|November 21, 2007
PubMed

Insights

Chronic kidney disease (CKD) is linked to coronary artery disease (CAD) in Chinese individuals with type 2 diabetes. Impaired renal function, indicated by serum creatinine and eGFR, independently predicts CAD in both men and women.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Chronic kidney disease (CKD) is a known risk factor for cardiovascular disease (CVD) in the general population.
  • Chinese individuals with type 2 diabetes (T2D) have a high risk of diabetic nephropathy but potentially a lower risk of coronary artery disease (CAD).
  • Investigating the relationship between renal function and CAD in this specific population is crucial.

Purpose of the Study:

  • To examine the impact of renal function on the prevalence of coronary artery disease (CAD) in Chinese patients with type 2 diabetes (T2D).
  • To identify specific markers of impaired renal function associated with CAD in this high-risk group.

Main Methods:

  • A cohort of 2,434 Chinese patients with T2D was analyzed.
  • Coronary artery disease (CAD) was diagnosed via medical history or electrocardiogram abnormalities.
  • Renal function was assessed using serum creatinine (SCr), estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR).

Main Results:

  • Patients with CAD were older, had higher SCr and BMI, and lower HDL-c levels.
  • Elevated SCr (>1.5 mg/dl), low eGFR (<60 ml/min), and high ACR (>30 mg/g) were independent CAD risk factors in diabetic men.
  • Elevated SCr (>1.4 mg/dl) and low eGFR (<60 ml/min) were independently associated with CAD in diabetic women.

Conclusions:

  • Impaired renal function, including elevated SCr and reduced eGFR, is significantly associated with CAD in Chinese patients with T2D.
  • CKD should be considered a cardiovascular disease (CVD) risk state in diabetic Chinese individuals.
  • Early detection and management of CKD may be vital for preventing CAD in this population.
Abstract

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