Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Setmelanotide for the Treatment of Acquired Hypothalamic Obesity.

The New England journal of medicine·2026
Same author

An open-label pilot study of psilocybin-assisted therapy for binge eating disorder.

Journal of eating disorders·2026
Same author

Diazoxide Choline Extended-release Tablets in Prader-Willi Syndrome: A Randomized, Double-blind, Withdrawal Period Study.

The Journal of clinical endocrinology and metabolism·2026
Same author

Blood Glucose Levels and Diabetes Family Conflict in Black Adolescents with Type 1 Diabetes During the COVID-19 Pandemic.

Behavioral medicine (Washington, D.C.)·2025
Same author

A proof-of-concept study of pitolisant for excessive daytime sleepiness in patients with Prader-Willi syndrome.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2025
Same author

Hyperphagia in rare melanocortin-4 receptor pathway diseases: therapeutic options and assessing treatment response.

Reviews in endocrine & metabolic disorders·2025

Related Experiment Video

Updated: Jun 27, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Management approaches for pediatric obesity.

Jennifer L Miller1, Janet H Silverstein

  • 1Division of Pediatric Endocrinology, University of Florida, Gainesville, FL 32610-0296, USA. millejl@peds.ufl.edu

Nature Clinical Practice. Endocrinology & Metabolism
|November 21, 2007
PubMed
Summary
This summary is machine-generated.

Childhood obesity is a global epidemic requiring urgent management. Prevention and early intervention are key, with lifestyle changes as the primary treatment for existing cases.

More Related Videos

An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Related Experiment Videos

Last Updated: Jun 27, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Area of Science:

  • Pediatrics
  • Public Health
  • Metabolic Disorders

Background:

  • Childhood obesity has reached epidemic proportions globally.
  • This leads to increased premature obesity-related morbidities and healthcare costs.
  • Effective management strategies are crucial for this growing public health concern.

Purpose of the Study:

  • To outline the importance of prevention and management of childhood obesity.
  • To emphasize the role of pediatricians in identifying at-risk children and monitoring obesity.
  • To discuss treatment modalities for childhood obesity, from lifestyle changes to last-resort interventions.

Main Methods:

  • Monitoring Body Mass Index (BMI) and identifying excessive weight gain in children.
  • Assessing and managing comorbidities associated with pediatric obesity.
  • Implementing practice-based counseling and community programs for lifestyle modification.

Main Results:

  • Prevention is considered the first line of management for childhood obesity.
  • Lifestyle modifications (diet and exercise) are the cornerstone of treatment.
  • Pharmacologic therapy or surgery are last-resort options for severe cases.

Conclusions:

  • Early intervention and prevention strategies are the most cost-effective approaches.
  • Pediatricians play a vital role in the early detection and management of childhood obesity.
  • A multi-faceted approach involving healthcare providers and community support is essential for combating this epidemic.