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Updated: Jul 10, 2026

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Nanoscale microcavity sensor for single particle detection.

Mindy R Lee1, Philippe M Fauchet

  • 1The Institute of Optics, University of Rochester, Rochester, New York 14627, USA. mindylee@optics.rochester.edu

Optics Letters
|November 21, 2007
PubMed
Summary
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This study presents a novel biosensor for detecting single particles, including virus-sized particles. The enhanced photonic crystal microcavity biosensor achieves high sensitivity for detecting minute amounts of matter.

Area of Science:

  • Photonics
  • Biosensing
  • Nanotechnology

Background:

  • Photonic crystal microcavities offer label-free detection of biomolecules.
  • Previous biosensor designs had limitations in sensitivity and detection volume.

Purpose of the Study:

  • To develop and validate a modified photonic crystal microcavity biosensor for single particle detection.
  • To assess the biosensor's capability in detecting minute quantities of matter within a small sensing volume.

Main Methods:

  • Theoretical modeling and experimental validation of a modified two-dimensional photonic crystal microcavity.
  • Testing the biosensor's performance using latex spheres of varying sizes, including those comparable to viruses.

Main Results:

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Last Updated: Jul 10, 2026

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
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A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
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A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

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  • The modified biosensor demonstrates the capability to detect approximately 1 femtogram (fg) of matter.
  • The device utilizes an active sensing volume of approximately 0.15 cubic micrometers (μm³).
  • Successful detection of latex spheres within the size range of various viruses was achieved.

    • Conclusions:

    • The developed biosensor significantly enhances sensitivity for single particle detection.
    • This technology holds promise for applications in virus detection and other nanoscale sensing challenges.