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Published on: July 29, 2022
Risk factors affecting morbidity in typhoid enteric perforation.
E Gedik1, S Girgin, I H Taçyildiz
1Department of General Surgery, Dicle University, Diyarbakir, Turkey. egedik@dicle.edu.tr
Langenbeck'S Archives of Surgery
|November 21, 2007
Summary
Factors like the Mannheim Peritonitis Index and a delayed operation-perforation interval significantly increase morbidity in typhoid enteric perforation. Early diagnosis and surgery are crucial for better outcomes in these cases.
Area of Science:
- Medical research
- Surgical outcomes
- Infectious disease complications
Background:
- Typhoid enteric perforation is a serious condition associated with high rates of illness and death.
- Identifying factors that influence patient outcomes is critical for improving care.
Purpose of the Study:
- To determine the factors affecting morbidity in patients who undergo surgery for typhoid enteric perforation.
Main Methods:
- A retrospective review of 96 patients with typhoid enteric perforation was conducted.
- Variables analyzed included patient demographics, clinical presentation, treatment history, laboratory values, and surgical findings.
- Multivariate logistic regression was used to identify independent risk factors for morbidity.
Main Results:
- Univariate analysis indicated several factors associated with morbidity, including male gender, shorter perforation-operation interval (≤48 hours), low hemoglobin, and high Mannheim Peritonitis Index.
- Logistic regression analysis identified the Mannheim Peritonitis Index (P = 0.014) and perforation-operation interval (P = 0.047) as independent risk factors for morbidity.
Conclusions:
- The severity of peritonitis, as indicated by the Mannheim Peritonitis Index, is an independent risk factor for morbidity in typhoid enteric perforation.
- Timely diagnosis and appropriate surgical intervention are essential to reduce morbidity and mortality associated with this condition.
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