Related Experiment Video
Updated: Jul 10, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
Recent developments in adaptive designs for Phase I/II dose-finding studies
1Inserm U717, Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Paris, France.
Abstract:
Cancer dose-finding trials aim at assessing the maximum tolerated dose (MTD) of a new treatment or combination. Owing to ethical constraint, they are based on adaptive designs, sequentially allocating patients to increased doses on the basis of previous responses. More recently, the concept of MTD has been extended to the largest concept of most successful or most desirable dose, based on efficacy criterion under toxicity restrictions. The aim of this paper is to present three main approaches proposed to estimate such a dose, in the setting of Phase I/II trials. Two case-studies allow to illustrate these new approaches.
More Related Videos
06:20Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
08:46Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
Related Concept Videos
Clinical Trials: Overview
Dosage Regimens: Designs and Approaches
Bioavailability Study Design: Single Versus Multiple Dose Studies
Clinical Trials
There are four phases in a clinical trial. A phase one...
Preclinical Development: Overview
Bioavailability Study Design: Healthy Subjects Versus Patients