Related Experiment Video
Updated: Jul 10, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Inflammatory response in on- versus off-pump myocardial revascularization: is ECC really the culprit?
J Börgermann1, R J Scheubel, A Simm
1Department of Cardiac and Thoracic Surgery, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany. jochen.boergermann@t-online.de
Abstract:
A review of inflammatory mediators in on- versus off-pump surgery reveals that parameters of systemic inflammation differ quantitatively, not qualitatively between these approaches. Mediator system and cellular activation is observed after surgical trauma and following ischemia/reperfusion. Such activation is also modulated by genetic factors. The available literature does not permit definitive conclusions to be made on the advantages of off-pump surgery with respect to the systemic inflammatory response. The relationship between mediator systems and clinical course needs to be assessed in large patient populations to demonstrate to what extent off-pump surgery is more than just theoretically superior to on-pump surgery.
Related Concept Videos
Myocarditis I: Introduction
Myocarditis III: Medical Management
Inflammatory Response I: Vascular and Cellular
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease V: Interprofessional Care
