Related Experiment Video
Updated: Jul 10, 2026
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Operative indications for lung cancer with idiopathic pulmonary fibrosis
K Kushibe1, T Kawaguchi, M Takahama
1Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Kashihara, Japan. n-thorac@m3.kcn.ne.jp
Background:
Idiopathic pulmonary fibrosis (IPF) is well known to be associated with lung cancer. However, surgical morbidity and mortality in lung cancer patients with IPF remains unclear.
Methods:
The data of patients who underwent surgery for non-small cell lung cancer were retrospectively reviewed.
Results:
Of the 1063 patients with lung cancer, 33 (3.1 %) had IPF. Patients with IPF had significantly higher postoperative pulmonary morbidity and mortality than those without IPF (33.3 vs. 2.0 %; 18.2 vs. 1.3 %, respectively, P < 0.0001). Patients with IPF had a significantly higher incidence of postoperative acute lung injury/acute respiratory distress syndrome (ALI/ARDS) than those without IPF (27.3 vs. 1.3 %, P < 0.0001). IPF patients with postoperative ALI/ARDS had a significantly lower preoperative %FVC than those without postoperative ALI/ARDS (74 +/- 9 vs. 103 +/- 14 %, P < 0.0001).
Conclusions:
Lung cancer patients with IPF who have a low preoperative %FVC should be carefully assessed prior to any surgical intervention.
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