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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
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Published on: September 24, 2020

[Remifentanil and its future: preface and comments].

Kazuo Hanaoka1

  • 1JR Tokyo General Hospital, Tokyo 151-8528.

Masui. the Japanese Journal of Anesthesiology
|November 22, 2007
PubMed
Summary
This summary is machine-generated.

Remifentanil, an ultra-short-acting opioid, offers rapid clearance for ambulatory surgery anesthesia. Its unique metabolism requires careful consideration for managing postoperative pain.

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Last Updated: Jul 10, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Remifentanil is a potent mu-opioid receptor agonist with pharmacodynamic similarities to fentanyl.
  • Unlike other opioids, remifentanil undergoes rapid metabolism by non-specific esterases, resulting in a unique pharmacokinetic profile.

Purpose of the Study:

  • To discuss the characteristics and clinical implications of remifentanil, a novel ultra-short-acting opioid, in Japanese anesthesiology.
  • To highlight the advantages of remifentanil for ambulatory surgery and address challenges in postoperative pain management.

Main Methods:

  • Review of remifentanil's receptor binding profile, including mu, delta, and kappa opioid receptors.
  • Analysis of remifentanil's pharmacokinetic properties, emphasizing its rapid clearance independent of organ function.
  • Discussion of clinical applications and future considerations for remifentanil in anesthesia.

Main Results:

  • Remifentanil exhibits strong mu-opioid receptor binding and is competitively antagonized by naloxone.
  • Its rapid metabolism by esterases leads to quick offset of action, making it suitable for ambulatory surgery.
  • No significant accumulation occurs, facilitating precise titration during anesthesia.

Conclusions:

  • Remifentanil's ultra-short duration and rapid clearance are advantageous for ambulatory anesthesia techniques.
  • Effective management of postoperative pain following remifentanil anesthesia requires careful planning.
  • Experts anticipate remifentanil will be a valuable addition to anesthesia practice in Japan.