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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

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Related Experiment Video

Updated: Jul 10, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

[Remifentanil in general anesthesia].

¹Department of Anesthesiology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519.

Masui. the Japanese Journal of Anesthesiology

|November 22, 2007

Summary

This summary is machine-generated.

Remifentanil, a potent opioid, offers rapid action and easy control for anesthesia. Its unique properties ensure patients remain free from surgical stress, potentially transforming anesthesia practices.

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Area of Science:

Anesthesiology
Pharmacology

Background:

Remifentanil is a potent mu-opioid receptor agonist.
It possesses distinct pharmacokinetic properties compared to fentanyl.

Purpose of the Study:

To explore the pharmacological advantages of remifentanil in anesthesia.
To discuss experiences and potential benefits for patient care.

Main Methods:

Review of remifentanil's pharmacokinetic and pharmacodynamic properties.
Analysis of clinical implications for general anesthesia.

Main Results:

Remifentanil exhibits rapid onset and offset of action.
Its concentration is easily titrated, allowing for precise control.
Quick emergence from anesthesia is observed, even after prolonged, high-dose administration.

Conclusions:

Remifentanil provides potent analgesia, effectively managing surgical stress during general anesthesia.
Its unique characteristics position it as a potential new trend in analgesia-oriented, opioid-based anesthesia.
Understanding and utilizing remifentanil can significantly improve patient care and alter anesthesia practice.