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[In vivo/in vitro evaluation of Kangfuxin colon targeting capsules]
Xue-lan Qiu1, Ming Yang, Xing-liang Xie
1Chengdu University of Traditional Chinanese Medicine, Chengdu 611730, China.
Objective:
To evaluate the release in fixed position of pH-dependent and enzyme-dependent Kangfuxin colon targeting capsules in vivo and in vitro.
Method:
The dissolution was tested in vitro and X-ray radiography was used for the evaluation in vivo.
Result:
After two hours pH-dependent colon targeting in man-made colon fluid, medicine release in fixed position on the whole, colon loc-release. Add enzyme into man-made colon, when enzyme-dependent colon targeting in it, then medicine release quickly, mainly release in fixed position; The conveying time in vivo of pH-dependent and enzyme-dependent capsules have big individuality difference. In the experiment, disintegration is stabilize among individuales, between 2.0-3.5 hours.
Conclusion:
Kangfuxin colon targeting capsules of two principles all release in fixed position to achieve the goal.
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