[Marginal and bone marrow pools of neutrophil granulocytes in patients with lung cancer]

Marginal and bone marrow pools of neutrophil leucocytes were studied in 194 patients with lung cancer, stage III-IV. Reactions of neutrophil marginal pools (adrenaline test) were characterized by the development of neutrophil leucocytosis (NL) in the peripheral blood of 64.5% of cases (typical reaction), or by NL absence in 35.5% (perversed reaction). The prednisolone test conducted for evaluation of bone-marrow pool of neutrophils has revealed perversed leucocytic reaction in 39.6% of patients. Unstable marginal pool and decreased bone marrow neutrophil reserve were recorded in the course of polychemotherapy. Changes in the prednisolone test indices precede the development of neutropenia in the peripheral blood.