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[Influence of PGLA degradable products on main physiologic function].

Jiao Sun¹, Shangchun Guo

¹No. 9 People's Hospital, Medical College of Shanghai Jiaotong University, Shanghai Biomaterial Research and Test Center, Shanghai 200023, China. jiaosun59@yahoo.com

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi

|November 22, 2007

Summary

Poly(lactic-co-glycolic acid) (PGLA) degradable products show no permanent harm to liver and kidney function in rats and rabbits. This self-control method effectively evaluates the biological safety of biodegradable materials.

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Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

Area of Science:

Biomaterials Science
Toxicology
Physiology

Background:

Assessing the biological safety of degradable products is crucial for biodegradable materials.
Poly(lactic-co-glycolic acid) (PGLA) is a common biodegradable material requiring safety evaluation.

Purpose of the Study:

To investigate the influence of PGLA degradable products on liver and kidney function.
To evaluate the efficacy of a self-control method using biochemical indexes for biological safety assessment.

Main Methods:

PGLA materials were implanted subcutaneously into Wistar rats and New Zealand rabbits.
Biochemical indexes including urea nitrogen, uric creatinine, blood urea nitrogen (BUN), carbamide (Cr), and serum glutamic pyruvic transaminase (GPT) were measured before and after implantation.
A control group underwent only surgical operation.

Main Results:

Temporary increases in urea nitrogen, uric creatinine, BUN, and Cr were observed 2-3 weeks post-implantation (P < 0.01).
A slight decrease in GPT was noted after 2 weeks (P < 0.05).
All indexes returned to normal levels by week 4 and remained stable; control groups showed no abnormalities.

Conclusions:

PGLA degradable products do not cause permanent harmful effects on liver and kidney function.
The self-control method using blood biochemical indexes is suitable and sensitive for evaluating the biological safety and bioacceptability of degradable products.
This method offers an objective, sensitive approach to observe dynamic changes in vivo, reducing animal numbers and providing a new avenue for biodegradable material evaluation.