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Updated: Jul 10, 2026

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
Published on: March 24, 2017
[Predication of secondary structures and epitopes of fusion protein pp150/MDBP]
Dadong Guo1, Xueqin Gao, Jinxiang Han
1Key Laboratory for Biotech-drugs, Ministry of Health Shandong Medicinal Biotechnology Centre, Ji'nan 250062, China.
Abstract:
The secondary structures of fusion protein pp150/MDBP, including alpha-helix, beta-sheet, turn regions, were analyzed by Garnier-Robson's and Chou-Fasman's methods; the antigenic epitopes of B cells were analysed by using hydrophilicity plot. The results showed that the fusion protein pp150/MDBP might have less alpha-helix, but be rich in beta-sheet and turn regions. The epitopes recognized by B cells may be at 7-56 amino acid residues or adjacent to 137-192 amino acid residues.
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