Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The affected sib-set method: revision based on the mixed model using a conditional probability approach].

A S Sergeev

    Genetika
    |November 1, 1991
    PubMed
    Summary

    This study addresses the affected sib-pair method in genetic linkage analysis. It highlights the need for explicitly stating the independence of single locus genotypes for theoretical validity, improving disease gene mapping.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Entrainment, stopping, and transmission of microwave solitons of self-induced transparency in counter-propagating magnetized electron beam.

    Chaos (Woodbury, N.Y.)·2022
    Same author

    [Endovascular Treatment of Critical Аоrtic Stenosis: Current State of the Problem and Perspectives].

    Kardiologiia·2018
    Same author

    Generation of Rogue Waves in Gyrotrons Operating in the Regime of Developed Turbulence.

    Physical review letters·2017
    Same author

    Generation of Subterahertz Superradiance Pulses Based on Excitation of a Surface Wave by Relativistic Electron Bunches Moving in Oversized Corrugated Waveguides.

    Physical review letters·2016
    Same author

    Using Two-Dimensional Distributed Feedback for Synchronization of Radiation from Two Parallel-Sheet Electron Beams in a Free-Electron Maser.

    Physical review letters·2016
    Same author

    Conversion of an electromagnetic wave into a periodic train of solitons under cyclotron resonance interaction with a backward beam of unexcited electron-oscillators.

    Physical review letters·2014

    Area of Science:

    • Genetics
    • Biostatistics
    • Computational Biology

    Context:

    • The affected sib-pair method is crucial for genetic linkage analysis.
    • Implicit assumptions in genetic models can affect analytical validity.
    • Understanding gene action independence is key for accurate linkage studies.

    Purpose:

    • To theoretically substantiate the affected sib-pair method by addressing implicit assumptions.
    • To propose a refined single locus model formulation that accounts for gene action independence.
    • To derive theoretical expectations for affected sib pairs under a mixed inheritance model.

    Summary:

    • This research emphasizes the necessity of explicitly stating the independence of single locus genotypes from the rest of the genotype in genetic models.

    Related Experiment Videos

  • It demonstrates how this assumption is critical for the theoretical foundation of the affected sib-pair method in linkage analysis.
  • The study derives theoretical proportions of affected sib pairs sharing haplotypes identical by descent (IBD) and discusses empirical assessment methods.

    • Impact:

    • Provides a more robust theoretical framework for linkage analysis using the affected sib-pair method.
    • Offers methods for empirical assessment of genetic data, improving disease gene mapping accuracy.
    • Enhances the understanding of gene action in complex disease inheritance models.