[Organ specificity of DNA damaging activity of dioxidine]

Dioxidine 2, 3-di (oxymethyl) quinoxaline-1,4-dioxide induced DNA breaks in lung cells of mice in vivo. The DNA was analysed for single strand breaks by alkaline elution assay. DNA damaging activity of dioxidine was compared with the activity of methyl methane sulfonate, N-nitrosomorpholine and 4-nitroquinoline-1,4-oxide.