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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Acute subcortical stroke and early serotonergic modification: a IDAP study.

A Rocco1, J Afra, M Toscano

  • 1Department of Neurological Sciences, University La Sapienza, Rome, Italy. andrea.rocco@uniroma1.it

European Journal of Neurology
|November 22, 2007
PubMed
Summary

This study found that acute stroke patients with depressive symptoms show altered auditory-evoked potentials (IDAP), indicating a direct involvement of the serotonergic system. This suggests a potential biomarker for post-stroke depression.

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Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Psychiatry

Background:

  • Depression is common after stroke, leading to poor outcomes.
  • The exact cause of post-stroke depression (PSD) is not fully understood.
  • Serotonergic tone, measured by intensity dependence of auditory-evoked potentials (IDAP), is linked to depression.

Purpose of the Study:

  • To investigate serotonergic tone in acute stroke patients using IDAP.
  • To explore the relationship between IDAP and depressive symptoms in stroke patients.
  • To understand the role of the serotonergic system in PSD.

Main Methods:

  • Auditory-evoked potentials (IDAP) were measured in acute stroke patients and healthy controls.
  • IDAP was quantified using the amplitude/stimulus intensity function (ASF) slope.
  • Patients were assessed for depressive symptoms (DS).

Main Results:

  • Stroke patients exhibited a significantly increased ASF slope compared to controls.
  • Stroke patients with depressive symptoms showed a steeper ASF slope than controls.
  • No significant difference in ASF slope was found between stroke patients without DS and controls.

Conclusions:

  • Acute stroke patients with depressive symptoms display altered serotonergic tone.
  • The serotonergic system appears directly involved in the pathophysiology of PSD.
  • IDAP may serve as a biomarker for detecting depressive symptoms in acute stroke.