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Long-term assessment of oxcarbazepine in a naturalistic setting: a retrospective study
U Seneviratne1, W D'Souza, M Cook
1Department of Clinical Neuroscience, St. Vincent's Hospital Melbourne, Fitzroy, Vic., Australia. wusenevi@optusnet.com.au
Background:
New antiepileptics seem to be better tolerated by patients. The retention rate of an antiepileptic would be a useful indicator of its practical usefulness.
Aims:
To assess the long-term outcome of oxcarbazepine (OXC) in a naturalistic setting by determining the retention rate.
Methods:
This is a retrospective study. All epilepsy patients treated with OXC at a tertiary care epilepsy center during a period of 3.5 years were included in this study. Retention rates of OXC at 1 and 3 years were estimated for each cohort group using Kaplan-Meier estimates and corresponding 95% confidence intervals.
Results:
A total of 98 patients were studied. OXC was used as monotherapy in 14 (14.3%) and as add-on therapy in 84 (85.7%). The mean daily dose was 947 +/- 492 mg and 60% received < or = 900 mg/day. Using the Kaplan-Meier survival analysis, the retention rates of OXC at 1 and 3 years were estimated to be 0.853 (0.749-0.956) and 0.737 (0.570-0.904), respectively.
Conclusions:
OXC is well tolerated by patients as both monotherapy and add-on therapy.
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