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Physicians' perceptions of adherence to prophylactic clotting factor infusions

C D Thornburg1

  • 1Duke University Medical Center, Durham, NC 27710, USA. thorn006@mc.duke.edu

Haemophilia : the Official Journal of the World Federation of Hemophilia
|November 22, 2007
PubMed

Insights

Physician concerns about poor adherence to prophylaxis in haemophilia patients often lead to reduced prescription rates. Strategies are needed to improve prophylaxis implementation and adherence in children with haemophilia.

Area of Science:

  • Pediatric Hematology
  • Bleeding Disorders Management
  • Patient Adherence Research

Background:

  • Haemophilia requires consistent prophylaxis for effective management.
  • Physician perceptions of patient adherence significantly influence treatment decisions.

Purpose of the Study:

  • To assess paediatric Haemophilia Treatment Centre (HTC) physicians' concerns regarding prophylaxis adherence.
  • To determine if these concerns impact prophylaxis prescription rates in haemophilia patients.

Main Methods:

  • A survey was administered to 59 HTC physicians.
  • Data collected included self-reported practices and beliefs about patient adherence.
  • Physicians' decisions on prophylaxis prescription were analyzed in relation to adherence concerns.

Main Results:

  • 86% of physicians routinely prescribed prophylaxis.
  • A majority (81%) reported that perceived non-adherence decreased their likelihood to prescribe prophylaxis.
  • 30% of physicians had withheld prophylaxis in the past year due to adherence concerns.

Conclusions:

  • Physician concerns about non-adherence are prevalent and affect prophylaxis prescription in paediatric haemophilia.
  • Developing strategies to improve prophylaxis implementation and adherence is crucial.

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