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Noggin is required for normal lobe patterning and ductal budding in the mouse prostate

Crist Cook1, Chad M Vezina, Sarah H Allgeier

  • 1Department of Surgery, University of Wisconsin, Box 3236 Clinical Science Center-G5, 600 Highland Ave., Madison, WI 53792, USA.

Developmental Biology
|November 22, 2007
PubMed
Summary

The BMP-NOGGIN axis is crucial for mouse prostate development. Loss of NOGGIN causes severe genitourinary anomalies and ventral prostate absence, while NOGGIN counteracts BMP4 to promote ductal budding.

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