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Lung function, respiratory symptoms, and the menopausal transition.

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Menopause is linked to reduced lung function and increased respiratory symptoms, particularly in leaner women. This study highlights significant changes in women

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Area of Science:

  • Reproductive Endocrinology
  • Pulmonary Medicine
  • Epidemiology

Background:

  • Limited data exists on respiratory health changes during the menopausal transition.
  • Understanding these changes is crucial for women's health during midlife.

Purpose of the Study:

  • To investigate the relationship between the menopausal transition and lung function.
  • To examine associations with asthma and respiratory symptoms.
  • To determine if body mass index (BMI) modifies these associations.

Main Methods:

  • Analysis of data from 1274 women aged 45-56 years not using hormone therapy.
  • Lung function measurements (FEV1, FVC) and hormonal status markers were assessed.
  • Logistic and linear regression models adjusted for BMI, age, smoking, and other factors.

Main Results:

  • Women in the late menopausal transition showed significantly lower lung function (FEV1, FVC) and more respiratory symptoms compared to regularly menstruating women.
  • These associations were more pronounced in women with lower BMI (<23 kg/m²).
  • Significantly stronger associations between menopausal transition and respiratory symptoms/lung function were observed in leaner women.

Conclusions:

  • The menopausal transition is associated with declines in lung function and an increase in respiratory symptoms.
  • Leaner women experiencing menopause are particularly susceptible to these adverse respiratory effects.
  • Findings underscore the importance of considering menopausal status and BMI in respiratory health assessments.