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Serum sickness-like reactions from cefaclor in children
A A Hebert1, E S Sigman, M L Levy
1Department of Dermatology, University of Texas Medical School, Houston 77030.
Insights
Cefaclor, an antibiotic for children's infections, can cause serum sickness-like reactions. Discontinuing the drug resolved symptoms in all reported cases without lasting issues.
Area of Science:
- Pediatric Pharmacology
- Infectious Disease Management
- Adverse Drug Reactions
Background:
- Cefaclor is a widely used oral cephalosporin antibiotic in pediatric medicine.
- Serum sickness-like reactions (SSLRs) are a known potential adverse effect of cefaclor.
Abstract:
Cefaclor is an oral semisynthetic cephalosporin that is popular in the treatment of infections in children. This drug has been associated with a serum sickness--like reaction characterized by an urticarial eruption, pruritus, arthritis, and/or arthralgias. We report 12 additional cases of cefaclor-related serum sickness--like reactions in children. All patients improved after discontinuation of the drug and no long-term complications resulted.