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Updated: Jul 10, 2026
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
Oral squamous cell carcinoma in children; review of an unusual entity
S A H Stolk-Liefferink1, A G Dumans, E H van der Meij
1Department of Oral and Maxillofacial Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Insights
Squamous cell carcinoma (SCC) of the oral cavity is rare in children. This report details an 11-year-old boy with gingival SCC and reviews pediatric oral SCC literature.
Area of Science:
- Oncology
- Pediatric Medicine
- Oral Pathology
Background:
- Squamous cell carcinoma (SCC) of the oral cavity typically affects individuals in their fifth and sixth decades.
- Cancers in patients under 40 years old are infrequent, representing less than 4% of cases.
- Oral SCC in pediatric patients (<=20 years) is exceptionally rare.
Observation:
- This report presents a case of an 11-year-old male diagnosed with SCC of the gingiva.
- The patient's age highlights the extreme rarity of this condition in the pediatric population.
Findings:
- The case underscores the occurrence of oral SCC in a pediatric patient, a demographic rarely affected.
- Literature review will provide further context on pediatric oral SCC.
Implications:
- This case contributes to the limited understanding of oral SCC in children.
- Highlights the need for awareness and consideration of rare diagnoses in pediatric oncology.
- Informs clinical practice regarding the diagnosis and management of oral SCC in young patients.
Abstract:
Most commonly, squamous cell carcinoma (SCC) of the oral cavity presents during the fifth and sixth decades of life. Less than 4% of these cancers occur in patients younger than 40 years of age. Only a small sample of this subgroup exists of pediatric patients (< or =20 years), making oral SCC in children an extremely rare entity. An 11-year-old boy is presented who developed a SCC of the gingiva. The relevant literature of oral SCC in pediatric patients will be reviewed as well.
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