Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Telomere dysfunction and stem cell ageing.

Zhenyu Ju1, K Lenhard Rudolph, Lenhard Rudolph

  • 1Institute of Molecular Medicine and Max-Planck-Research Group on Stem Aging, Ulm University, Ulm, Germany.

Biochimie
|November 22, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hematopoietic Rejuvenation via Natural Senolytic NSPCC1 Delays Inflammatory Aging.

Biology·2026
Same author

Lithospermic acid-induced gut microbiota remodeling alleviates intraplaque inflammation.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Succinate antagonizes α-ketoglutarate biosynthesis governing myeloid differentiation in normal hematopoiesis and myelodysplastic syndromes.

Science bulletin·2026
Same author

HuR coordinates systemic aging through platelet infiltration.

Nature communications·2026
Same author

SETDB1 enhances starvation-induced lipophagy by inhibiting m<sup>6</sup>A-mediated mRNA decay via DDX5 methylation.

Autophagy·2026
Same author

A <i>Ganoderma lucidum</i> Extract Improves Mitochondrial Function in Aging Skin and Promotes Wound Healing.

Clinical, cosmetic and investigational dermatology·2026
Same journal

Differential cardiac microRNA expression in anoxic Trachemys scripta elegans turtles.

Biochimie·2026
Same journal

Renal failure-driven luminal ammonia production impairs gut barrier function in CKD.

Biochimie·2026
Same journal

Conditional Knockout of Indoleamine 2, 3-Dioxygenase-1 in Osteoprogenitor Cells in Mice Results in Sex-dependent Differences in Bone Mass.

Biochimie·2026
Same journal

Sedentariness disrupts, while exercise restores, thermogenic and metabolic plasticity in inguinal adipose tissue of mice.

Biochimie·2026
Same journal

Chrononutrition as a modulator of retinal metabolic resilience: A translational framework linking circadian biology to ocular disease.

Biochimie·2026
Same journal

Heterologous expression, purification, and biophysical characterisation of the cobalt-dependent nitrile hydratase from Rhodococcus rhodochrous ATCC BAA-870.

Biochimie·2026
See all related articles

Ageing involves stem cell decline, partly due to telomere shortening. This telomere dysfunction impairs adult stem cell function and tissue repair, contributing to the ageing process.

Area of Science:

  • Gerontology
  • Cell Biology
  • Molecular Biology

Background:

  • Ageing is marked by reduced organ maintenance and repair capabilities.
  • Adult stem cells are crucial for tissue repair and organ maintenance.
  • A decline in stem cell function is a potential contributor to ageing.

Purpose of the Study:

  • To review the role of telomere dysfunction in adult stem cell ageing.
  • To summarize current knowledge on molecular mechanisms of ageing related to stem cells.

Main Methods:

  • Literature review focusing on telomere biology and stem cell ageing.
  • Analysis of molecular damage accumulation during ageing.
  • Examination of DNA damage checkpoints and cell cycle regulation.

Related Experiment Videos

Main Results:

  • Telomere shortening is a cell-intrinsic aging mechanism causing DNA damage.
  • Telomere dysfunction triggers checkpoints that impair adult stem cell maintenance and function.
  • Altered stem cell environments due to telomere dysfunction further limit stem cell activity.

Conclusions:

  • Telomere dysfunction significantly contributes to adult stem cell ageing.
  • Understanding these mechanisms is key to addressing age-related decline in tissue repair.