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Updated: Jul 10, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Body size, body composition, and metabolic profile explain higher energy expenditure in overweight children
Nancy F Butte1, Maurice R Puyau, Firoz A Vohra
1USDA/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. nbutte@bcm.edu
Insights
Overweight children expend more energy, but this is mainly due to larger body size and composition, not altered metabolism. Differences in energy expenditure, efficiency, and fuel use were not evident in overweight children after adjustments.
Area of Science:
- Pediatric Endocrinology
- Human Metabolism
- Obesity Research
Background:
- Obesity in children is often linked to altered energy metabolism, including lower energy expenditure and increased efficiency.
- However, these associations have not been consistently proven in overweight pediatric populations.
Purpose of the Study:
- To investigate differences in energy metabolism between nonoverweight and overweight children.
- To determine if body size, composition, thyroid hormones, or sympathoadrenal activity explain these metabolic differences.
Main Methods:
- 24-hour calorimetry, anthropometry, and dual-energy X-ray absorptiometry were performed on 836 Hispanic children (5-19 years).
- Biochemical analyses included thyroid hormones, catecholamines, and lipids.
- Statistical adjustments were made for body size and composition.
Main Results:
- Absolute total energy expenditure (TEE) and its components were higher in overweight children.
- Overweight children exhibited lower net mechanical energetic efficiency during cycling.
- Adjusting for body size and composition eliminated differences in TEE, its components, and energetic efficiency.
- Net carbohydrate and fat utilization did not differ between groups.
Conclusions:
- Higher energy expenditure in overweight children is primarily explained by larger body size and composition.
- Minor contributions from thyroid and sympathoadrenal systems were observed.
- No significant alterations in energy expenditure, energetic efficiency, or substrate utilization were evident in overweight children after accounting for body composition.
Abstract:
Lower relative rates of energy expenditure (EE), increased energetic efficiency, and altered fuel utilization purportedly associated with obesity have not been demonstrated indisputably in overweight children. We hypothesized that differences in energy metabolism between nonoverweight and overweight children are attributable to differences in body size and composition, circulating thyroid hormones, sympathetic nervous system, and adrenomedullary activity. A total of 836 Hispanic children, 5-19 y old, participated in 24-h calorimetry, anthropometric, and dual-energy X-ray absorptiometry measurements. Biochemistries were determined by standard techniques. Absolute total EE (TEE) and its components (sleep EE, basal EE, sedentary EE, cycling EE, walking EE, activity EE, nonexercising activity thermogenesis) were higher in overweight children (P = 0.001). Net mechanical energetic efficiency of cycling was lower in overweight children (P = 0.001). Adjusting for body size and composition accounted for differences in TEE, its components, and energetic efficiency. Net carbohydrate and fat utilization did not differ between groups. TEE was independently influenced by sex, Tanner stage, fat free mass, fat mass (FM), fasting serum nonesterified fatty acids (NEFA), leptin, free thyroxine, triiodothyronine, and 24-h urinary norepinephrine and epinephrine. Fat utilization was independently associated with age2, sex, FM, fasting serum NEFA, triacylglycerol, adiponectin, leptin, total thyroxine, and free triiodothyronine. Higher EE in overweight children was largely explained by differences in body size and composition, with minor contributions of thyroid and sympathoadrenal systems. Alterations in EE, energetic efficiency, and substrate utilization were not evident in the overweight children.
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