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Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Detection of Central Nervous System Pathogens
10:08

Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Detection of Central Nervous System Pathogens

Published on: April 17, 2026

Antimicrobial susceptibility of cerebrospinal isolates from patients with meningitis

A Liskova1, J Benca, E Kalavsky

  • 1St Charles Lwanga Clinic, Tropical Project of St Elizabeth University College, Buikwe, Uganda.

Neuro Endocrinology Letters
|November 22, 2007
PubMed

Insights

This study found high susceptibility rates of common bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, Neisseria meningitidis, and Haemophilus influenzae, to older antibiotics. Low antibiotic usage is suggested as a key factor in maintaining this antibiotic susceptibility.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Stewardship

Background:

  • Antibiotic resistance is a growing global health concern.
  • Understanding local patterns of bacterial susceptibility is crucial for effective treatment.

Purpose of the Study:

  • To determine the antibiotic susceptibility profiles of key bacterial pathogens.
  • To investigate potential reasons for observed susceptibility patterns.

Main Methods:

  • Isolates of Streptococcus pneumoniae, Staphylococcus aureus, Neisseria meningitidis, and Haemophilus influenzae were tested.
  • Standard antimicrobial susceptibility testing methods were employed.

Main Results:

  • High susceptibility rates were observed for Streptococcus pneumoniae to penicillin, ofloxacin, chloramphenicol, cefotaxim, and cotrimoxazole.
  • Staphylococcus aureus isolates showed 100% susceptibility to oxacillin and chloramphenicol, and 95% to cotrimoxazole.
  • Neisseria meningitidis demonstrated high susceptibility to penicillin, cefotaxim, chloramphenicol, and cotrimoxazole.
  • Haemophilus influenzae isolates were fully susceptible to ampicillin, chloramphenicol, ofloxacin, and cotrimoxazole.

Conclusions:

  • The study highlights surprisingly high susceptibilities to older antibiotics.
  • Low antibiotic consumption and usage are proposed as primary drivers for maintaining these susceptibility levels.
  • This underscores the importance of judicious antibiotic stewardship in preventing resistance.

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