Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Planarians, a tale of stem cells.

L Rossi1, A Salvetti, R Batistoni

  • 1Dipartimento di Morfologia Umana e Biologia Applicata, Sezione di Biologia e Genetica, Università di Pisa, Via Volta, 4, 56126, Pisa, Italy. leoros@biomed.unipi.it

Cellular and Molecular Life Sciences : CMLS
|November 22, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The use of bone-modifying agents in early breast cancer: AIOM Guidelines update and perspectives.

Tumori·2025
Same author

PREDICTIVE BRCA GENETIC TESTING IN ITALIAN PATIENTS WITH BREAST CANCER: A POSITION PAPER OF ITALIAN SCIENTIFIC SOCIETIES [Italian Association of Medical Oncology(AIOM); Italian Association of Radiotherapy and Clinical Oncology (AIRO); Italian National Association of Breast Surgeons (ANISC); Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP); Italian Society of Surgical Oncology (SICO); Italian Society of Human Genetic (SIGU); Italian Society of General Practice (SIMG); Italian Society of Medical and Interventional Radiology (SIRM)].

Cancer treatment reviews·2025
Same author

Capsid Engineering Overcomes Barriers Toward Adeno-Associated Virus Vector-Mediated Transduction of Endothelial Cells.

Human gene therapy·2019
Same author

Host and symbiont intraspecific variability: The case of Paramecium calkinsi and "Candidatus Trichorickettsia mobilis".

European journal of protistology·2017
Same author

Delivery of therapeutic proteins from genetically-modified cells.

Restorative neurology and neuroscience·2011
Same author

Obesity in the childhood: a link to adult hypertension.

Current pharmaceutical design·2009
Same journal

Elektra-Qki and Alien-Wt1 lncRNA-protein interaction controls myocardial ion channel expression and epicardial EMT during heart development in mice.

Cellular and molecular life sciences : CMLS·2026
Same journal

SHIP1 is required for T cell surveillance of occult malignancies.

Cellular and molecular life sciences : CMLS·2026
Same journal

Reply to: Commentary on "The food additive 4-hexylresorcinol impairs intestinal stem cell function and exacerbates inflammatory bowel disease in Drosophila melanogaster via suppression of MAPK signaling pathway".

Cellular and molecular life sciences : CMLS·2026
Same journal

The BmCPV-derived viral small peptide vsp1S4(-) suppresses viral replication by triggering apoptosis via the ROS-JNK signalling pathway.

Cellular and molecular life sciences : CMLS·2026
Same journal

UBE2L6 promotes invasion and metastasis of triple-negative breast cancer by enhancing autophagy through STK38 ISGylation.

Cellular and molecular life sciences : CMLS·2026
Same journal

Inhibition of ferroptosis via SLC25A39-NRF2 axis drives Osimertinib resistance in lung adenocarcinoma.

Cellular and molecular life sciences : CMLS·2026
See all related articles

Planarian stem cells, called neoblasts, are crucial for tissue homeostasis and regeneration. Recent research reveals neoblast heterogeneity, suggesting multiple stem cell types contribute to their remarkable regenerative abilities.

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Planarians exhibit exceptional tissue homeostasis and regeneration capabilities.
  • This regeneration relies on a population of pluripotent stem cells known as neoblasts.
  • Neoblasts are the sole proliferating cells in asexual planarian strains.

Purpose of the Study:

  • To investigate the distribution and heterogeneity of planarian neoblasts.
  • To explore the communication between neoblasts and differentiated cells.
  • To understand how neoblast self-renewal and differentiation are regulated.

Main Methods:

  • Mapping neoblast distribution using bromodeoxyuridine incorporation.
  • Analysis of mitotic figures and cell proliferation markers.

Related Experiment Videos

  • Identification of molecular markers for neoblast subgroups.

    • Main Results:

    • Neoblast distribution was mapped using various cell proliferation techniques.
    • Newly identified molecular markers indicate neoblast heterogeneity.
    • Evidence suggests neoblast totipotency arises from the combined activity of multiple stem cell types.

    Conclusions:

    • Planarian neoblasts are not a single cell type but a heterogeneous population.
    • Understanding neoblast heterogeneity is key to comprehending planarian regeneration.
    • Molecular resources facilitate new strategies for studying planarian stem cells and regeneration.