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Isothermal DNA amplification with gold nanosphere-based visual colorimetric readout for herpes simplex virus

Eric Tan1, Barbara Erwin, Shale Dames

  • 1Keck Graduate Institute of Applied Life Sciences, Claremont, CA 91711, USA.

Clinical Chemistry
|November 22, 2007
PubMed
Abstract

No abstract available in PubMed .

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Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...