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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
Published on: February 6, 2018
[Catalytically active antibodies (abzymes) in human milk]
Ukrains'Kyi Biokhimichnyi Zhurnal (1999 )
|November 23, 2007
Summary
This review examines catalytic antibodies (abzymes) in human milk, exploring their origins and roles in regulating milk compounds. A hypothesis suggests these abzymes may offer epithelial cell defense against viral infections.
Area of Science:
- Biochemistry
- Immunology
- Molecular Biology
Context:
- Human colostrum and milk contain unique enzymatic antibodies, known as abzymes.
- These abzymes possess catalytic activity, suggesting a functional role beyond typical antibody functions.
Purpose:
- To review and analyze existing data on the catalytic activity of human milk abzymes.
- To explore the potential origins and biological regulatory roles of these abzymes.
- To propose a hypothesis regarding the involvement of secretory abzymes in innate immunity.
Summary:
- Analysis of published data reveals the catalytic capabilities of human milk abzymes.
- The review discusses potential mechanisms for abzyme generation and their influence on milk compound activity.
- A novel hypothesis posits that secretory abzymes contribute to non-specific humoral defense of epithelial cells against viral infections.
Impact:
- Provides insights into the multifaceted roles of antibodies in biological systems.
- Highlights the potential of abzymes in human milk for immune defense mechanisms.
- Suggests new avenues for research into antibody catalysis and innate immunity.
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