Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endogenous IL-10 protects mice from death during septic peritonitis.

Journal of immunology (Baltimore, Md. : 1950)·1995
Same author

Effects of prenatal ultrasound exposure on adult offspring behavior in the Wistar rat.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·1995
Same author

Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholics cirrhosis.

Hepatology (Baltimore, Md.)·1995
Same author

Differential effect of human immunodeficiency virus infection on the IgA and IgG antibody responses to pneumococcal vaccine.

The Journal of infectious diseases·1995
Same author

Interleukin-5 production by T lymphocytes in atheroembolic disease with hypereosinophilia.

The Journal of allergy and clinical immunology·1995
Same author

Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells.

European journal of immunology·1995

Related Experiment Video

Updated: Jul 10, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

Interleukin-10: actions and therapeutic potential.

M Goldman1, T Velu, M Pretolani

  • 1Department of Immunology, Hôpital Erasme, and Laboratory of Experimental Immunology, Université Libre de Bruxelles, Bruxelles, Belgium.

Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
|January 1, 1997
PubMed
Summary

Interleukin-10 (IL-10) is a cytokine with dual anti-inflammatory and immunostimulatory roles. Recombinant IL-10 (rIL-10) shows therapeutic promise but requires careful patient selection due to varied effects.

More Related Videos

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

Related Experiment Videos

Last Updated: Jul 10, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

Area of Science:

  • Immunology
  • Cytokine Biology
  • Molecular Medicine

Background:

  • Interleukin-10 (IL-10) is a cytokine with significant anti-inflammatory and immunosuppressive functions.
  • IL-10 deactivates macrophages and monocytes, inhibiting antigen-presenting cells and T cells.
  • IL-10 also exhibits immunostimulatory effects on B cells, CD8+ cytotoxic T cells, and natural killer cells.

Purpose of the Study:

  • To review the multifaceted roles of IL-10 in experimental immunopathology.
  • To evaluate the therapeutic potential and challenges of recombinant IL-10 (rIL-10) in various disease models.

Main Methods:

  • In vivo administration of rIL-10 in experimental models of septic shock, autoimmune diseases, cancer, and infections.
  • Analysis of rIL-10's effects on immune cell function and disease outcomes.

Main Results:

  • rIL-10 prevents experimental septic shock and T helper type 1 (T(H)1) cell-mediated autoimmune diseases.
  • rIL-10 demonstrates paradoxical effects in cancer, promoting tumor rejection, but exacerbates experimental infections and lupus.
  • rIL-10's efficacy is context-dependent, influenced by its stimulatory properties on cytotoxic cells.

Conclusions:

  • The therapeutic application of rIL-10 in human diseases is promising but complex.
  • Clinical success hinges on precise patient selection and vigilant monitoring for adverse effects due to IL-10's diverse immunomodulatory actions.