Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Not Available].

C A Wallace1

  • 1Department of Pediatrics, Division of Immunology and Rheumatology, University of Washington, and Children's Hospital and Medical Center, Seattle, Washington, USA.

Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Environmental Risk Factors and Early-Life Exposures in Juvenile Idiopathic Arthritis: A Case-Control Study.

Arthritis care & research·2015
Same author

Long-term safety and effectiveness of etanercept in children with selected categories of juvenile idiopathic arthritis.

Arthritis and rheumatism·2009
Same author

Stress-Related Changes in beta-Endorphin Processing: The Limitations of Slaughterhouse Material.

Journal of neuroendocrinology·2009
Same author

The Cutaneous Assessment Tool: development and reliability in juvenile idiopathic inflammatory myopathy.

Rheumatology (Oxford, England)·2007
Same author

Macrophage activation syndrome and other systemic inflammatory conditions after BMT.

Bone marrow transplantation·2006
Same author

Regulation of granulocyte-macrophage colony-stimulating factor in human retinal pigment epithelial cells by IL-1beta and IFN-gamma.

Cellular immunology·2001
Same journal

Gene Therapy Strategies for Uveal Melanoma: Adeno-associated Virus Delivery Challenges and Translational Opportunities.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
Same journal

Review of Quality Attributes and Analytical Methods Used for Comparative Analytical Assessment of Monoclonal Antibodies as Part of Successful Biosimilar Approvals in the United States and European Union.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
Same journal

Impact of Repeated Antigen Exposure on Humoral Tolerance: Antidrug Antibodies After Single-Dose Versus Multi-dose Adalimumab.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
Same journal

An Overview and Trend Analysis of Biosimilar Approvals in China.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
Same journal

Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
Same journal

mRNA Vaccines for Influenza: Hope for a Universal Vaccine?

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
See all related articles

Rheumatologists should not biopsy all patients on methotrexate. Instead, assess individual liver damage risk using patient factors, medications, and lab tests.

Area of Science:

  • Rheumatology
  • Hepatology
  • Clinical Decision-Making

Background:

  • Methotrexate is a common medication for rheumatologic conditions.
  • Liver damage is a potential side effect of methotrexate therapy.
  • Determining the need for liver biopsy in methotrexate patients is challenging.

Purpose of the Study:

  • To provide guidance on when to perform liver biopsies in patients taking methotrexate.
  • To identify factors influencing the decision for liver biopsy.
  • To optimize patient care and resource utilization.

Main Methods:

  • Review of clinical guidelines and literature.
  • Analysis of factors influencing methotrexate-induced liver injury.
  • Discussion of diagnostic strategies for liver assessment.

Related Experiment Videos

Main Results:

  • Routine liver biopsies are not cost-effective or medically indicated for all patients on methotrexate.
  • Individual patient assessment is crucial for determining biopsy necessity.
  • Pre-existing conditions, alcohol use, and concurrent medications impact liver health.

Conclusions:

  • Clinicians should consider patient-specific factors like hepatitis, diabetes, obesity, alcohol consumption, and concomitant medications when deciding on liver biopsy.
  • Serial laboratory evaluations are important in monitoring methotrexate patients.
  • A personalized approach is recommended for assessing methotrexate-related liver damage.