Related Experiment Video
Updated: Jul 10, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Autoimmune ocular disorders
L V Rizzo1, S M Whitcup, R B Nussenblatt
1Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Abstract:
The ability of orally presented antigen to induce a state of tolerance has been recognised for many years. The use of this immunological phenomenon of oral tolerance to treat autoimmune diseases is a more recent development in the field of mucosal immunology. Ocular autoimmunity is especially intriguing because of the unique immunological characteristics of the eye. On the basis of laboratory data, the ;feeding' of ocular antigens has been proposed as a safe and efficacious therapy for uveitis. Two patients with uveitis have been successfully treated with oral administration of retinal S-antigen, and a larger phase I/II trial of oral tolerance as a treatment for uveitis is currently being completed at the National Eye Institute.
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