Related Experiment Video
Updated: Jul 10, 2026
12:12
Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice
Published on: February 8, 2016
Traditional and high potency probiotic preparations for oral bacteriotherapy
G Famularo1, C De Simone, D Matteuzzi
1San Camillo Hospital, Rome, Italy.
Summary
Oral bacteriotherapy, using probiotics, shows promise for gastrointestinal and systemic disorders. Newer high-potency preparations enriched in lactic acid bacteria offer greater clinical effectiveness and are key for future research.
Area of Science:
- Microbiology
- Gastroenterology
- Pharmacology
Background:
- Growing understanding of endogenous digestive microflora fuels interest in oral bacteriotherapy.
- Oral bacteriotherapy is being explored for various gastrointestinal and systemic conditions.
Purpose of the Study:
- To review the current state of oral probiotic preparations for bacteriotherapy.
- To discuss challenges and future directions in the clinical development of oral probiotics.
Main Methods:
- Review of current research on oral probiotic preparations.
- Analysis of clinical trial data and potential obstacles.
Main Results:
- Newer high-potency probiotic preparations, rich in lactic acid bacteria, demonstrate enhanced clinical potential.
- These advanced preparations are under evaluation for conditions like inflammatory bowel disease, irritable bowel syndrome, and cryptosporidiosis.
Conclusions:
- Significant progress in oral bacteriotherapy requires continued collaboration between scientists, clinicians, and industry.
- High-potency probiotics represent a promising area for future biomedical research and clinical application.
Related Concept Videos
01:22Probiotics
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
01:29Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...