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Updated: Jul 9, 2026

Immunolabelling Myofiber Degeneration in Muscle Biopsies
Published on: December 5, 2019
Diagnosis of limb-girdle muscular dystrophy 2A by immunohistochemical techniques
Hanna K Kolski1, Cynthia Hawkins, Mayana Zatz
1Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. hanna.kolski@capitalhealth.ca
Abstract:
The Western blot technique is currently the standard detection method for suspected limb girdle muscular dystrophy (LGMD) 2A (calpainopathy). This is the first report in the English literature of the successful application of immunohistochemical techniques to support a diagnosis of LGMD 2A. This approach is straightforward and appears to be reasonably specific. We propose that immunohistochemical methods should be re-evaluated for the screening of undiagnosed patients with suspected LGMD 2A.
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