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Neuroplasticity

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Related Experiment Video

Updated: Jul 9, 2026

Whole-cell Patch-clamp Recordings in Brain Slices

Whole-cell Patch-clamp Recordings in Brain Slices

Published on: June 15, 2016

Ubiquitous plasticity and memory storage.

Sang Jeong Kim¹, David J Linden

¹Department of Physiology, Seoul National University College of Medicine, 110-799 Seoul, Korea. sangjkim@snu.ac.kr

|November 23, 2007

Summary

Memory storage involves more than just synaptic plasticity. Recent findings show other neuronal components also exhibit long-term plasticity, improving memory models.

Area of Science:

Neuroscience
Cellular Electrophysiology
Memory Research

Background:

Traditional memory storage hypotheses center on long-term potentiation and depression (LTP/LTD) of excitatory postsynaptic currents (EPSCs).
This focus overlooks other crucial electrophysiological mechanisms within neurons.

Purpose of the Study:

To broaden the scope of memory storage models beyond traditional synaptic plasticity.
To investigate the role of diverse electrophysiological components in neuronal plasticity and memory.

Main Methods:

Review and synthesis of recent findings on use-dependent long-term plasticity in various neuronal components.
Development of computational models incorporating a wider range of plastic electrophysiological elements.

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Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

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Last Updated: Jul 9, 2026

Whole-cell Patch-clamp Recordings in Brain Slices

Whole-cell Patch-clamp Recordings in Brain Slices

Published on: June 15, 2016

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

Main Results:

Identified multiple neuronal elements, including electrical synapses, glutamate transporters, and ion channels, exhibiting long-term plasticity.
Demonstrated that these additional plastic components are crucial for realistic memory storage.

Conclusions:

A comprehensive understanding of memory storage requires considering plasticity across diverse neuronal electrophysiological components.
Integrated models better explain behavioral measures of memory storage, indexing, and recall.