Related Experiment Video
Updated: Jul 9, 2026

05:55
How to Create Conditioned Taste Aversion for Grazing Ground Covers in Woody Crops with Small Ruminants
Published on: April 30, 2016
Toxicity in goats caused by oleander (Nerium oleander)
R R Barbosa1, J D Fontenele-Neto, B Soto-Blanco
1Department of Animal Sciences, UFERSA-BR, Mossoró-RN, Brazil.
Research in Veterinary Science
|November 23, 2007
Summary
Oleander (Nerium oleander) poisoning in goats caused apathy, colic, and renal necrosis. Goats showed similar toxic responses to oleander as other species, with death occurring rapidly after high doses.
Area of Science:
- Veterinary Toxicology
- Cardiovascular Pathology
- Renal Pathology
Background:
- Oleander (Nerium oleander) is a toxic plant affecting various animal species.
- Goats have historically shown resistance to oleander poisoning.
- Limited data exists on the specific pathological effects of oleander in goats.
Purpose of the Study:
- To investigate the clinical and pathological effects of Nerium oleander poisoning in goats.
- To determine if goats exhibit similar toxicological responses to oleander as other species.
Main Methods:
- Three groups of goats were used: a control group and two experimental groups receiving varying doses of oleander leaves.
- Clinical signs were monitored, and electrocardiograms were performed.
- Post-mortem microscopic evaluation of renal and cardiac tissues was conducted.
Main Results:
- Goats exhibited clinical signs including apathy, colic, hyperpnea, and moderate rumen distention.
- Electrocardiograms revealed second-degree atrioventricular block.
- Histopathology showed renal necrosis in tubules and slight myocardial degeneration.
Conclusions:
- Goats are susceptible to Nerium oleander poisoning, displaying pathological effects similar to other species.
- The study confirms oleander toxicity in goats, characterized by cardiovascular and renal damage.
- Rapid death occurred following high-dose oleander administration in goats.
Related Concept Videos
Toxicity Testing in Animals
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Drug Toxicity: Overview
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Drug Toxicity: Risk factors
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Toxic Reactions: Overview
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Drug Toxicity: Dose-Dependent Reactions
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...