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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

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Related Experiment Video

Updated: Jul 9, 2026

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
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3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

Published on: October 4, 2017

Controlled drug delivery in tissue engineering.

Marco Biondi1, Francesca Ungaro, Fabiana Quaglia

  • 1Interdisciplinary Research Centre on Biomaterials (CRIB), University of Naples Federico II, Naples, Italy.

Advanced Drug Delivery Reviews
|November 23, 2007
PubMed
Summary

Advanced biomaterials mimic the natural cellular environment to guide tissue regeneration. These scaffolds deliver specific molecules, showing promise in bone repair, blood vessel growth, and stem cell control.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • The cellular microenvironment significantly influences tissue development and cellular functions.
  • Advancements in understanding this microenvironment drive the creation of novel biomaterials.
  • Current biomaterials aim to replicate the extracellular matrix's structure and molecular cues.

Purpose of the Study:

  • To highlight the evolution of tissue and cell guidance concepts.
  • To discuss the role of advanced biomaterials in mimicking native tissue environments.
  • To explore the potential of these biomaterials in regenerative medicine.

Main Methods:

  • Development of micro- and nano-structured scaffolds.
  • Incorporation of biomolecular sequestration and delivery capabilities.
  • Integration of material engineering, drug delivery, and cell/molecular biology.

Main Results:

  • Demonstrated efficacy of scaffolds in bone repair.
  • Successful guidance of functional angiogenesis (blood vessel formation).
  • Effective control over stem cell differentiation pathways.

Conclusions:

  • Current biomaterial platforms represent initial steps in mimicking in vivo conditions.
  • Future biomaterials will require greater integration of multiple scientific disciplines.
  • Enhanced biomaterials hold potential for precise control over tissue-specific development and organogenesis.