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Developmental decrease in short-term facilitation at Schaffer collateral synapses in hippocampus is mGluR1 sensitive.

Haley E Speed1, Lynn E Dobrunz

  • 1Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.

Journal of Neurophysiology
|November 23, 2007
PubMed
Summary
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Short-term synaptic facilitation decreases with age in rats. This developmental change is mediated by metabotropic glutamate receptor 1 (mGluR1) activation, which increases GABA release, inhibiting synaptic function.

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Developmental Biology

Background:

  • Short-term plasticity, the dynamic property of synapses, changes during development.
  • Previous studies showed decreased short-term facilitation in adult rats compared to juveniles at Schaffer collateral synapses.
  • This developmental decrease occurs in response to complex, naturalistic stimulus patterns.

Purpose of the Study:

  • Investigate the mechanism underlying the developmental decrease in short-term facilitation at 32°C.
  • Determine the role of metabotropic glutamate receptor 1 (mGluR1) in this developmental change.
  • Identify downstream signaling pathways involved in mGluR1-mediated effects on synaptic plasticity.

Main Methods:

  • Utilized acute hippocampal slices from juvenile and adult rats at 32°C.

Related Experiment Videos

  • Applied mGluR1 antagonist LY367385 to assess its effect on facilitation.
  • Investigated the involvement of cannabinoid and GABA(B) receptors using specific blockers.

    • Main Results:

    • The developmental decrease in short-term facilitation was observed at 32°C.
    • Synaptic activation of mGluR1 by glutamate occurs at both ages, with a larger effect in adults.
    • Blocking mGluR1 significantly reduced the developmental decrease in facilitation.
    • Blocking GABA(B) receptors increased facilitation and occluded the mGluR1 antagonist effect, suggesting mGluR1 modulates GABA release.

    Conclusions:

    • Synaptic activation of mGluR1 on inhibitory interneurons contributes to the developmental decrease in short-term facilitation.
    • mGluR1 activation leads to increased GABA release, which then inhibits Schaffer collateral synapses via GABA(B) receptors.
    • This mechanism explains the age-related reduction in short-term facilitation during naturalistic stimulation.